Heparin Sodium has 23 known drug interactions based on U.S. FDA drug labeling data. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Andexanet Alfa, Antithrombin Iii (Human), Dicumarol. Patients taking Heparin Sodium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 23
- Major
- 5
- Moderate
- 18
Major (5)
- Heparin Sodium + Andexanet Alfa— Andexanet binds to heparin-bound antithrombin III and may reduce heparin's anticoagulant effect, potentially leading to …
- Heparin Sodium + Antithrombin Iii (Human)— Enhances heparin anticoagulant effect in patients with hereditary antithrombin III deficiency; reduced heparin dosage re…
- Heparin Sodium + Dicumarol— Heparin may prolong prothrombin time; at least 5 hours after IV or 24 hours after SC heparin dose should elapse before b…
- Heparin Sodium + Nitroglycerin— Intravenous nitroglycerin may decrease partial thromboplastin time with rebound effect upon discontinuation. Careful mon…
- Heparin Sodium + Warfarin Sodium— Heparin may prolong prothrombin time; at least 5 hours after IV or 24 hours after SC heparin dose should elapse before b…
Moderate (18)
- Heparin Sodium + Abciximab— 7.2 Platelet Inhibitors Drugs such as NSAIDS (including salicylic acid, ibuprofen, indomethacin, and celecoxib), dextran…
- Heparin Sodium + Antihistamines— May partially counteract the anticoagulant action of heparin. Careful monitoring recommended.
- Heparin Sodium + Aspirin— May interfere with platelet aggregation and induce bleeding. Use with caution in heparinized patients; dose reduction of…
- Heparin Sodium + Celecoxib— Interferes with platelet aggregation and may induce bleeding. Use with caution; dose reduction of antiplatelet agent or …
- Heparin Sodium + Dextran— Interferes with platelet aggregation and may induce bleeding. Use with caution; dose reduction of antiplatelet agent or …
- Heparin Sodium + Digitalis Glycosides— May partially counteract the anticoagulant action of heparin. Careful monitoring recommended.
- Heparin Sodium + Dipyridamole— Interferes with platelet aggregation and may induce bleeding. Use with caution; dose reduction of antiplatelet agent or …
- Heparin Sodium + Eptifibatide— Glycoprotein IIb/IIIa antagonist that interferes with platelet aggregation and may induce bleeding. Use with caution; do…
- Heparin Sodium + Hydroxychloroquine— Interferes with platelet aggregation and may induce bleeding. Use with caution; dose reduction of antiplatelet agent or …
- Heparin Sodium + Ibuprofen— Interferes with platelet aggregation and may induce bleeding. Use with caution; dose reduction of antiplatelet agent or …
- Heparin Sodium + Indomethacin— Interferes with platelet aggregation and may induce bleeding. Use with caution; dose reduction of antiplatelet agent or …
- Heparin Sodium + Nicotine— May partially counteract the anticoagulant action of heparin. Careful monitoring recommended.
- Heparin Sodium + Phenylbutazone— Interferes with platelet aggregation and may induce bleeding. Use with caution; dose reduction of antiplatelet agent or …
- Heparin Sodium + Phytonadione— Heparin sodium may be used as an alternative anticoagulant when phytonadione has caused resistance to prothrombin-depres…
- Heparin Sodium + Salicylic Acid— Interferes with platelet aggregation and may induce bleeding. Use with caution; dose reduction of antiplatelet agent or …
- Heparin Sodium + Tetracycline— May partially counteract the anticoagulant action of heparin. Careful monitoring recommended.
- Heparin Sodium + Thienopyridines— Interfere with platelet aggregation and may induce bleeding. Use with caution; dose reduction of antiplatelet agent or h…
- Heparin Sodium + Tirofiban— Glycoprotein IIb/IIIa antagonist that interferes with platelet aggregation and may induce bleeding. Use with caution; do…