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Nafcillin Sodium

Also known as: Nafcillin

Route: Intravenous

5 interactions on record

Nafcillin Sodium has 5 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cyclosporine, Tetracycline, Warfarin. Patients taking Nafcillin Sodium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 5
Major: 3

Major (3)

Nafcillin Sodium + Cyclosporine— Nafcillin concomitant use results in subtherapeutic cyclosporine levels. Cyclosporine levels should be monitored in orga…
Nafcillin Sodium + Tetracycline— Tetracycline may antagonize the bactericidal effect of nafcillin; concurrent use should be avoided.
Nafcillin Sodium + Warfarin— Nafcillin in high doses (2 grams every 4 hours) decreases warfarin effects. Prothrombin time requires close monitoring a…

Nafcillin Sodium + Cyclosporine⚠️Major

Nafcillin concomitant use results in subtherapeutic cyclosporine levels. Cyclosporine levels should be monitored in organ transplant patients.

Nafcillin Sodium + Tetracycline⚠️Major

Tetracycline may antagonize the bactericidal effect of nafcillin; concurrent use should be avoided.

Nafcillin Sodium + Warfarin⚠️Major

Nafcillin in high doses (2 grams every 4 hours) decreases warfarin effects. Prothrombin time requires close monitoring and warfarin dose adjustment. Effect may persist up to 30 days after nafcillin discontinuation.

Nafcillin Sodium + Nafcillinℹ️Unknown

Nafcillin in high dosage regimens, i.e., 2 grams every 4 hours, has been reported to decrease the effects of warfarin. When nafcillin and warfarin are used concomitantly, the prothrombin time should be closely monitored and the dose of warfarin adjusted as necessary. This effect may persist for up to 30 days after nafcillin has been discontinued.

Nafcillin Sodium + Penicillinℹ️Unknown

Drug Interactions Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin, and concurrent use of these drugs should be avoided.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.