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Penicillin G Sodium

Also known as: Penicillin G Sodium

Route: Intramuscular, Intravenous

Check Penicillin G Sodium Interactions →

12 interactions on record

Penicillin G Sodium has 12 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Acetazolamide, Acetylsalicylic Acid, Andthiazide. Patients taking Penicillin G Sodium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 12
Moderate: 11

Moderate (11)

Penicillin G Sodium + Acetazolamide— May antagonize the bactericidal effect of penicillin and may compete for renal tubular secretion. Concurrent use should …
Penicillin G Sodium + Acetylsalicylic Acid— Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
Penicillin G Sodium + Andthiazide— Compete with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
Penicillin G Sodium + Chloramphenicol— May antagonize the bactericidal effect of penicillin. Concurrent use should be avoided, though clinical significance is …
Penicillin G Sodium + Erythromycin— May antagonize the bactericidal effect of penicillin. Concurrent use should be avoided, though clinical significance is …
Penicillin G Sodium + Ethacrynic Acid— Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
Penicillin G Sodium + Furosemide— Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
Penicillin G Sodium + Indomethacin— Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
Penicillin G Sodium + Phenylbutazone— Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
Penicillin G Sodium + Probenecid— Prolongs penicillin blood levels by blocking renal tubular secretion of penicillins.
Penicillin G Sodium + Tetracycline— May antagonize the bactericidal effect of penicillin. Concurrent use should be avoided, though clinical significance is …

Penicillin G Sodium + Acetazolamide🟡Moderate

May antagonize the bactericidal effect of penicillin and may compete for renal tubular secretion. Concurrent use should be avoided.

Penicillin G Sodium + Acetylsalicylic Acid🟡Moderate

Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.

Penicillin G Sodium + Andthiazide🟡Moderate

Compete with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.

Penicillin G Sodium + Chloramphenicol🟡Moderate

May antagonize the bactericidal effect of penicillin. Concurrent use should be avoided, though clinical significance is not well-documented.

Penicillin G Sodium + Erythromycin🟡Moderate

May antagonize the bactericidal effect of penicillin. Concurrent use should be avoided, though clinical significance is not well-documented.

Penicillin G Sodium + Ethacrynic Acid🟡Moderate

Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.

Penicillin G Sodium + Furosemide🟡Moderate

Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.

Penicillin G Sodium + Indomethacin🟡Moderate

Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.

Penicillin G Sodium + Phenylbutazone🟡Moderate

Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.

Penicillin G Sodium + Probenecid🟡Moderate

Prolongs penicillin blood levels by blocking renal tubular secretion of penicillins.

Penicillin G Sodium + Tetracycline🟡Moderate

May antagonize the bactericidal effect of penicillin. Concurrent use should be avoided, though clinical significance is not well-documented.

Penicillin G Sodium + Penicillinℹ️Unknown

Drug Interactions Bacteriostatic antibacterials (i.e., chloramphenicol, erythromycins, sulfonamides or tetracyclines) may antagonize the bactericidal effect of penicillin, and concurrent use of these drugs should be avoided. Penicillin blood levels may be prolonged by concurrent administration of probenecid which blocks the renal tubular secretion of penicillins. Other drugs may compete with Penicillin G for renal tubular secretion and thus prolong the serum half-life of penicillin.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.