Sotalol has 15 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 10 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Macimorelin Acetate, Pimozide, Clarithromycin. Patients taking Sotalol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 15
- Contraindicated
- 2
- Major
- 10
- Moderate
- 3
Contraindicated (2)
- Sotalol + Macimorelin Acetate— Co-administration may lead to torsade de pointes-type ventricular tachycardia due to QT prolongation. Avoid concomitant …
- Sotalol + Pimozide— Additive QT interval prolongation effect anticipated, increasing risk of ventricular arrhythmias.
Major (10)
- Sotalol + Clarithromycin— Antiarrhythmic affected by clarithromycin CYP3A inhibition. Risk of QTc prolongation and torsades de pointes.
- Sotalol + Digoxin— Proarrhythmic events more common with concurrent use. Increased risk of arrhythmias with concomitant administration.
- Sotalol + Etrasimod— Class III anti-arrhythmic drug that may increase risk of QT prolongation and Torsades de Pointes due to additive effects…
- Sotalol + Foscarnet Sodium— Should be avoided due to risk of QT prolongation and torsades de pointes.
- Sotalol + Moxifloxacin Hydrochloride— Class III antiarrhythmic that may further increase QTc interval when combined with moxifloxacin, with proarrhythmic effe…
- Sotalol + Ozanimod Hydrochloride— Class III anti-arrhythmic; associated with Torsades de Pointes in bradycardia patients. Cardiologist advice recommended …
- Sotalol + Ponesimod— Class III anti-arrhythmic drug associated with Torsades de Pointes in bradycardic patients; should generally not be init…
- Sotalol + Siponimod— Class III antiarrhythmic associated with Torsades de Pointes in bradycardia patients; should generally not be initiated …
- Sotalol + Tetrabenazine— Class III antiarrhythmic that prolongs QTc interval. Concomitant use should be avoided due to additive QTc prolongation …
- Sotalol + Toremifene Citrate— Class III antiarrhythmic that prolongs QT interval; should be avoided with toremifene citrate or requires close monitori…
Moderate (3)
- Sotalol + Haloperidol Decanoate— Class 3 antiarrhythmic known to prolong QTc interval; caution advised when used with haloperidol decanoate due to risk o…
- Sotalol + Haloperidol Lactate— Class 3 antiarrhythmic that prolongs QTc interval; caution advised when used with haloperidol due to risk of QT prolonga…
- Sotalol + Lidocaine And Prilocaine— Class III antiarrhythmic drug; specific interaction studies not performed but caution is advised when used with lidocain…