Does Alprazolam Interact with Oral Contraceptives?
Alprazolam and Oral Contraceptives have a moderate drug interaction according to U.S. FDA drug labeling data. Increased alprazolam maximum plasma concentration by 18%, decreased clearance by 22%, and increased half-life by 29%. The mechanism involves cyp3a inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Alprazolam Class
- Benzodiazepine
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Alprazolam and Oral Contraceptives occurs because cyp3a inhibition. Clinically, this means increased alprazolam maximum plasma concentration by 18%, decreased clearance by 22%, and increased half-life by 29%. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Alprazolam and your doctor is considering prescribing Oral Contraceptives (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider