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Does Angiotensin Ii Interact with Azathioprine?

Angiotensin Ii and Azathioprine have a major drug interaction according to U.S. FDA drug labeling data. Use to control hypertension has been reported to induce anemia and severe leukopenia in patients on azathioprine. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Angiotensin Ii Class
Vasoconstrictor
Azathioprine Class
Purine Antimetabolite
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Angiotensin Ii and your doctor is considering prescribing Azathioprine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Angiotensin Ii(Giapreza)+💊 Azathioprine(Imuran)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Vasoconstrictor
Drug B class
Purine Antimetabolite
Source
NLP:azathioprine

What this means in plain English

Use to control hypertension has been reported to induce anemia and severe leukopenia in patients on azathioprine.

About Angiotensin Ii and Azathioprine

Angiotensin Ii is a Vasoconstrictor, while Azathioprine is a Purine Antimetabolite. You may recognize them by the brand names Giapreza and Imuran. Angiotensin Ii is given by intravenous (IV) infusion, whereas Azathioprine is taken by mouth. Azathioprine additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.