Does Angiotensin Ii Interact with Eplerenone?
CDI records a major classification for Angiotensin Ii and Eplerenone. The stored summary is: Combination increases risk of hyperkalemia. Monitor serum potassium and renal function closely, especially in elderly or those with impaired renal function. The mechanism involves additive potassium-sparing effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Angiotensin Ii Class
- Vasoconstrictor
- Eplerenone Class
- Aldosterone Antagonist
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Additive potassium-sparing effects
What To Tell Your Doctor or Pharmacist
If you are taking Angiotensin Ii and your doctor is considering prescribing Eplerenone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider