Does Anti Inhibitor Coagulant Complex Interact with Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide?
Anti Inhibitor Coagulant Complex and Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide have a moderate drug interaction according to U.S. FDA drug labeling data. Co-administration may result in increased plasma concentrations of darunavir and cobicistat. The mechanism involves decreased metabolism of darunavir and cobicistat by cyp3a inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide Class
- Cytochrome P450 3A Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Anti Inhibitor Coagulant Complex and Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide occurs because decreased metabolism of darunavir and cobicistat by cyp3a inhibition. Clinically, this means co-administration may result in increased plasma concentrations of darunavir and cobicistat. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Anti Inhibitor Coagulant Complex and your doctor is considering prescribing Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider