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Does Armodafinil Interact with Esketamine Hydrochloride?

Armodafinil and Esketamine Hydrochloride have a moderate drug interaction according to U.S. FDA drug labeling data. Concomitant use may increase blood pressure. Closely monitor blood pressure with concomitant use. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Armodafinil and your doctor is considering prescribing Esketamine Hydrochloride (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Armodafinil(Nuvigil)+💊 Esketamine Hydrochloride(Spravato)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:esketamine hydrochloride

What this means in plain English

Concomitant use may increase blood pressure. Closely monitor blood pressure with concomitant use.

About Armodafinil and Esketamine Hydrochloride

You may recognize them by the brand names Nuvigil and Spravato. Armodafinil is taken by mouth, whereas Esketamine Hydrochloride is given as a nasal spray. Esketamine Hydrochloride additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.