Does Armodafinil Interact with Phenytoin?
CDI records a moderate classification for Armodafinil and Phenytoin. The stored summary is: Elimination of phenytoin may be prolonged by armodafinil via inhibition of metabolic enzymes, resulting in higher systemic exposure. Dose reduction may be required. The mechanism involves inhibition of cyp2c19 metabolic enzymes. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Phenytoin Class
- Anti-epileptic Agent
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of CYP2C19 metabolic enzymes
What To Tell Your Doctor or Pharmacist
If you are taking Armodafinil and your doctor is considering prescribing Phenytoin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider