Does Avanafil Interact with Alcohol?
Avanafil and Alcohol have a moderate drug interaction according to U.S. FDA drug labeling data. Substantial alcohol consumption (>3 units) with avanafil increases orthostatic signs and symptoms including increased heart rate, decreased standing blood pressure, dizziness, and headache. The mechanism involves both act as vasodilators with additive blood pressure-lowering effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Avanafil Class
- Phosphodiesterase 5 Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Avanafil and Alcohol occurs because both act as vasodilators with additive blood pressure-lowering effects. Clinically, this means substantial alcohol consumption (>3 units) with avanafil increases orthostatic signs and symptoms including increased heart rate, decreased standing blood pressure, dizziness, and headache. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Avanafil and your doctor is considering prescribing Alcohol (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider