Avanafil + Amlodipine Interaction
Unknowninteraction on record
Description
A clinical pharmacology trial was conducted to assess the effect of avanafil on the potentiation of the blood pressure-lowering effects of selected antihypertensive medications (amlodipine and enalapril). CYP3A4 Substrate When administered with avanafil 200 mg, amlodipine (5 mg daily) increased the C max and AUC of avanafil by approximately 22% and 70%, respectively. The C max and AUC of amlodipine decreased by approximately 9% and 4%, respectively [see Dosage and Administration ( 2.3 )].
Source: FDA drug label - avanafil