Home›Avanafil›Avanafil + Enalapril

Does Avanafil Interact with Enalapril?

CDI records a moderate classification for Avanafil and Enalapril. The stored summary is: Clinical pharmacology trial showed additional blood pressure reductions of 3-5 mmHg when enalapril was co-administered with avanafil 200 mg. The mechanism involves additive vasodilatory effects on blood pressure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.

Severity
Moderate
Avanafil Class
Phosphodiesterase 5 Inhibitor
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

Recorded Mechanism

Additive vasodilatory effects on blood pressure

What To Tell Your Doctor or Pharmacist

If you are taking Avanafil and your doctor is considering prescribing Enalapril (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Avanafil(Stendra)+💊 Enalapril(Epaned)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Phosphodiesterase 5 Inhibitor
Drug B class
—
Source
NLP:avanafil

What this means in plain English

Clinical pharmacology trial showed additional blood pressure reductions of 3-5 mmHg when enalapril was co-administered with avanafil 200 mg.

About Avanafil and Enalapril

Avanafil is a Phosphodiesterase 5 Inhibitor. You may recognize them by the brand names Stendra and Epaned. Enalapril additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: NLP:avanafil

Recent research & FDA safety updates

Live

Auto-aggregated from PubMed E-utilities and FDA safety data.

Share this result:

WhatsAppText / SMSEmail
Also share on:XFacebook
Add more drugs
Check Avanafil and Enalapril against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →
How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.

CDI: source-linked explanations