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Does Bupropion Hydrochloride Interact with Cimetidine?

Bupropion Hydrochloride and Cimetidine have a moderate drug interaction according to U.S. FDA drug labeling data. Cimetidine increased AUC and Cmax of threohydrobupropion and erythrohydrobupropion metabolites by 16% and 32%, respectively, but did not affect bupropion and hydroxybupropion pharmacokinetics. The mechanism involves inhibition of bupropion metabolite metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Cimetidine Class
Histamine-2 Receptor Antagonist
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Bupropion Hydrochloride and Cimetidine occurs because inhibition of bupropion metabolite metabolism. Clinically, this means cimetidine increased auc and cmax of threohydrobupropion and erythrohydrobupropion metabolites by 16% and 32%, respectively, but did not affect bupropion and hydroxybupropion pharmacokinetics. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Bupropion Hydrochloride and your doctor is considering prescribing Cimetidine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Bupropion Hydrochloride(Bupropion Hydrochloride (Xl))+💊 Cimetidine(Cimetidine)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Histamine-2 Receptor Antagonist
Source
NLP:bupropion hydrochloride

What this means in plain English

Cimetidine increased AUC and Cmax of threohydrobupropion and erythrohydrobupropion metabolites by 16% and 32%, respectively, but did not affect bupropion and hydroxybupropion pharmacokinetics.

What the FDA label says

"Inhibition of bupropion metabolite metabolism"

📖 Source: NLP:bupropion hydrochloride

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.