Does Bupropion Hydrochloride Interact with Thiotepa?
Bupropion Hydrochloride and Thiotepa have a unknown drug interaction according to U.S. FDA drug labeling data. Potential drug interaction as thiotepa is a CYP2B6 substrate or inhibitor; bupropion is metabolized by CYP2B6. The mechanism involves cyp2b6 enzyme interaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Thiotepa Class
- Alkylating Drug
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Bupropion Hydrochloride and Thiotepa occurs because cyp2b6 enzyme interaction. Clinically, this means potential drug interaction as thiotepa is a cyp2b6 substrate or inhibitor; bupropion is metabolized by cyp2b6.
What To Tell Your Doctor or Pharmacist
If you are taking Bupropion Hydrochloride and your doctor is considering prescribing Thiotepa (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider