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Does Cholestyramine Light Interact with Digitalis Glycosides?

Cholestyramine Light and Digitalis Glycosides have a major drug interaction according to U.S. FDA drug labeling data. Cholestyramine may delay or reduce digitalis absorption; discontinuance poses hazard if digitalis was titrated to maintenance level during cholestyramine use. The mechanism involves binding and reduced absorption; potential toxicity on discontinuance. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Cholestyramine Light Class
Bile Acid Sequestrant
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Cholestyramine Light and Digitalis Glycosides occurs because binding and reduced absorption; potential toxicity on discontinuance. Clinically, this means cholestyramine may delay or reduce digitalis absorption; discontinuance poses hazard if digitalis was titrated to maintenance level during cholestyramine use. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Cholestyramine Light and your doctor is considering prescribing Digitalis Glycosides (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Cholestyramine Light(Cholestyramine Light)+💊 Digitalis Glycosides

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Bile Acid Sequestrant
Drug B class
—
Source
NLP:cholestyramine

What this means in plain English

Cholestyramine may delay or reduce digitalis absorption; discontinuance poses hazard if digitalis was titrated to maintenance level during cholestyramine use.

What the FDA label says

"Binding and reduced absorption; potential toxicity on discontinuance"

📖 Source: NLP:cholestyramine

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.