Home›Cholestyramine Light›Cholestyramine Light + Mycophenolate Mofetil

Does Cholestyramine Light Interact with Mycophenolate Mofetil?

Cholestyramine Light and Mycophenolate Mofetil have a major drug interaction according to U.S. FDA drug labeling data. Cholestyramine decreases MPA AUC by approximately 40%. Not recommended for concomitant use due to interruption of enterohepatic recirculation. The mechanism involves binding of recirculating mpag in intestine, interrupting enterohepatic recirculation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Cholestyramine Light Class
Bile Acid Sequestrant
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Cholestyramine Light and Mycophenolate Mofetil occurs because binding of recirculating mpag in intestine, interrupting enterohepatic recirculation. Clinically, this means cholestyramine decreases mpa auc by approximately 40%. not recommended for concomitant use due to interruption of enterohepatic recirculation. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Cholestyramine Light and your doctor is considering prescribing Mycophenolate Mofetil (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Cholestyramine Light(Cholestyramine Light)+💊 Mycophenolate Mofetil(Cellcept)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Bile Acid Sequestrant
Drug B class
—
Source
NLP:mycophenolate mofetil

What this means in plain English

Cholestyramine decreases MPA AUC by approximately 40%. Not recommended for concomitant use due to interruption of enterohepatic recirculation.

What the FDA label says

"Binding of recirculating MPAG in intestine, interrupting enterohepatic recirculation"

📖 Source: NLP:mycophenolate mofetil

Share this result:XFacebookWhatsAppReddit
Add more drugs
Check Cholestyramine Light and Mycophenolate Mofetil against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.