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Does Cimetidine Interact with Saxagliptin And Metformin Hydrochloride?

Cimetidine and Saxagliptin And Metformin Hydrochloride have a major drug interaction according to U.S. FDA drug labeling data. OCT2/MATE inhibitor that reduces metformin clearance, increasing systemic exposure and risk for lactic acidosis. The mechanism involves inhibits organic cationic transporter-2 (oct2) and mate renal transport. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Cimetidine Class
Histamine-2 Receptor Antagonist
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Cimetidine and Saxagliptin And Metformin Hydrochloride occurs because inhibits organic cationic transporter-2 (oct2) and mate renal transport. Clinically, this means oct2/mate inhibitor that reduces metformin clearance, increasing systemic exposure and risk for lactic acidosis. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Cimetidine and your doctor is considering prescribing Saxagliptin And Metformin Hydrochloride (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Cimetidine(Tagamet)+💊 Saxagliptin And Metformin Hydrochloride(Kombiglyze)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Histamine-2 Receptor Antagonist
Drug B class
—
Source
NLP:saxagliptin and metformin

What this means in plain English

OCT2/MATE inhibitor that reduces metformin clearance, increasing systemic exposure and risk for lactic acidosis.

About Cimetidine and Saxagliptin And Metformin Hydrochloride

Cimetidine is a Histamine-2 Receptor Antagonist. You may recognize them by the brand names Tagamet and Kombiglyze. Both medications are taken by mouth. Saxagliptin And Metformin Hydrochloride additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Inhibits organic cationic transporter-2 (OCT2) and MATE renal transport"

📖 Source: NLP:saxagliptin and metformin

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.