Does Ciprofloxacin Interact with Rifapentine?
CDI records a moderate classification for Ciprofloxacin and Rifapentine. The stored summary is: Rifapentine may increase metabolism and decrease activity. Dosage adjustment may be necessary. The mechanism involves cyp450 3a4/2c8/9 induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Ciprofloxacin Class
- Fluoroquinolone Antibacterial
- Rifapentine Class
- Rifamycin Antimycobacterial
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP450 3A4/2C8/9 induction
What To Tell Your Doctor or Pharmacist
If you are taking Ciprofloxacin and your doctor is considering prescribing Rifapentine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider