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Does Cisplatin Interact with Rituximab And Hyaluronidase?

Cisplatin and Rituximab And Hyaluronidase have a major drug interaction according to U.S. FDA drug labeling data. Renal toxicity when used in combination with cisplatin. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Cisplatin Class
Platinum-based Drug
Rituximab And Hyaluronidase Class
Endoglycosidase
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Cisplatin and your doctor is considering prescribing Rituximab And Hyaluronidase (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Cisplatin(Cisplatin)+💊 Rituximab And Hyaluronidase(Rituxan Hycela)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Platinum-based Drug
Drug B class
Endoglycosidase
Source
NLP:rituximab and hyaluronidase

What this means in plain English

Renal toxicity when used in combination with cisplatin.

About Cisplatin and Rituximab And Hyaluronidase

Cisplatin is a Platinum-based Drug, while Rituximab And Hyaluronidase is an Endoglycosidase. Rituximab And Hyaluronidase is also sold under the brand name Rituxan Hycela. Cisplatin is given by intravenous (IV) infusion, whereas Rituximab And Hyaluronidase is given by injection under the skin. Both Cisplatin and Rituximab And Hyaluronidase carry an FDA boxed warning — the agency's most serious safety designation.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.