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Does Clarithromycin Interact with Ranitidine Bismuth Citrate?

CDI records a minor classification for Clarithromycin and Ranitidine Bismuth Citrate. The stored summary is: Clarithromycin increases plasma ranitidine concentrations (57%), bismuth trough concentrations (48%), and 14-hydroxy-clarithromycin (31%). These effects are clinically insignificant. The mechanism involves clarithromycin inhibits ranitidine and bismuth metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.

Severity: Minor
Clarithromycin Class: Macrolide Antimicrobial
Management: Generally manageable
Data Source: U.S. FDA via OpenFDA

Recorded Mechanism

Clarithromycin inhibits ranitidine and bismuth metabolism

What To Tell Your Doctor or Pharmacist

If you are taking Clarithromycin and your doctor is considering prescribing Ranitidine Bismuth Citrate (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Never stop or change either medication without first consulting your healthcare provider

💊 Clarithromycin(Biaxin)+💊 Ranitidine Bismuth Citrate

Severity & Interaction Details

✅

minor

Minor classification in CDI

This classification is not an individual safety assessment. Ask your pharmacist how the record applies to your medications.

Severity scale

MinorContra

On record

Yes

Drug A class

Macrolide Antimicrobial

Drug B class

—

Source

NLP:clarithromycin

What this means in plain English

Clarithromycin increases plasma ranitidine concentrations (57%), bismuth trough concentrations (48%), and 14-hydroxy-clarithromycin (31%). These effects are clinically insignificant.

About Clarithromycin and Ranitidine Bismuth Citrate

Clarithromycin is a Macrolide Antimicrobial. Clarithromycin is also sold under the brand name Biaxin.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: NLP:clarithromycin

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How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.