Does Clomipramine Hydrochloride Capsules Interact with Methylphenidate?
CDI records a moderate classification for Clomipramine Hydrochloride Capsules and Methylphenidate. The stored summary is: Methylphenidate may increase plasma levels of clomipramine; close supervision and dosage adjustment recommended. The mechanism involves hepatic enzyme inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Methylphenidate Class
- Central Nervous System Stimulant
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Hepatic enzyme inhibition
What To Tell Your Doctor or Pharmacist
If you are taking Clomipramine Hydrochloride Capsules and your doctor is considering prescribing Methylphenidate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider