Does Clopidogrel Interact with Lansoprazole?
Clopidogrel and Lansoprazole have a moderate drug interaction according to U.S. FDA drug labeling data. CYP2C19 inhibitor with less effect on clopidogrel antiplatelet activity compared to omeprazole or esomeprazole. The mechanism involves cyp2c19 inhibition reduces active metabolite formation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Clopidogrel Class
- P2Y12 Platelet Inhibitor
- Lansoprazole Class
- Proton Pump Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Clopidogrel and Lansoprazole occurs because cyp2c19 inhibition reduces active metabolite formation. Clinically, this means cyp2c19 inhibitor with less effect on clopidogrel antiplatelet activity compared to omeprazole or esomeprazole. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Clopidogrel and your doctor is considering prescribing Lansoprazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider