Does Cobicistat Interact with Atazanavir?
CDI records a moderate classification for Cobicistat and Atazanavir. The stored summary is: Cobicistat inhibits CYP3A and CYP2D6, potentially increasing plasma concentrations of atazanavir and altering concentrations of concomitant drugs metabolized by these enzymes. The mechanism involves cyp3a and cyp2d6 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Cobicistat Class
- Cytochrome P450 3A Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP3A and CYP2D6 inhibition
What To Tell Your Doctor or Pharmacist
If you are taking Cobicistat and your doctor is considering prescribing Atazanavir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider