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Does Corticosteroids Interact with Natalizumab?

Corticosteroids and Natalizumab have a major drug interaction according to U.S. FDA drug labeling data. Should be tapered in Crohn's disease patients on chronic corticosteroids when starting natalizumab therapy due to increased infection risk. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Natalizumab Class
Integrin Receptor Antagonist
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Corticosteroids and your doctor is considering prescribing Natalizumab (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Corticosteroids(Neo-Polycin HC)+💊 Natalizumab(Tyruko)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Integrin Receptor Antagonist
Source
NLP:natalizumab

What this means in plain English

Should be tapered in Crohn's disease patients on chronic corticosteroids when starting natalizumab therapy due to increased infection risk.

About Corticosteroids and Natalizumab

Natalizumab is an Integrin Receptor Antagonist. You may recognize them by the brand names Neo-Polycin HC and Tyruko. Natalizumab is given by intravenous (IV) infusion. Natalizumab additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.