Does Cyclosporine Interact with Golimumab?
CDI records a moderate classification for Cyclosporine and Golimumab. The stored summary is: Golimumab may normalize CYP450 enzyme formation, potentially affecting cyclosporine metabolism. Monitoring and dose adjustment recommended. The mechanism involves tnf antagonism normalizes cyp450 enzyme formation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Cyclosporine Class
- Calcineurin Inhibitor Immunosuppressant
- Golimumab Class
- Tumor Necrosis Factor Blocker
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
TNF antagonism normalizes CYP450 enzyme formation
What To Tell Your Doctor or Pharmacist
If you are taking Cyclosporine and your doctor is considering prescribing Golimumab (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider