Does Cyclosporine Interact with Rifaximin?
Cyclosporine and Rifaximin have a moderate drug interaction according to U.S. FDA drug labeling data. P-glycoprotein inhibitor that significantly increased systemic exposure of rifaximin. In hepatic impairment, potential additive effect of reduced metabolism may further increase rifaximin exposure. Caution should be exercised. The mechanism involves p-glycoprotein and oatp inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Cyclosporine Class
- Calcineurin Inhibitor Immunosuppressant
- Rifaximin Class
- Rifamycin Antibacterial
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Cyclosporine and Rifaximin occurs because p-glycoprotein and oatp inhibition. Clinically, this means p-glycoprotein inhibitor that significantly increased systemic exposure of rifaximin. in hepatic impairment, potential additive effect of reduced metabolism may further increase rifaximin exposure. caution should be exercised. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Cyclosporine and your doctor is considering prescribing Rifaximin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider