Cyp3a Inducers + Phenobarbital Sodium Interaction

Moderateinteraction on record

Description

Inducers may decrease phenobarbital exposure, reducing efficacy and increasing risk of breakthrough seizures. Closely monitor and consider dosage adjustment.

Mechanism

Phenobarbital is a substrate of CYP2C9, CYP2C19, CYP2E1, and UGTs; induction increases metabolism

Source: NLP:phenobarbital sodium