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Does Darunavir Ethanolate And Cobicistat Interact with Ritonavir?

Darunavir Ethanolate And Cobicistat and Ritonavir have a unknown drug interaction according to U.S. FDA drug labeling data. Switching from darunavir co-administered with ritonavir to PREZCOBIX in patients on bosentan : Maintain bosentan dose. Patients switching from darunavir co-administered with ritonavir to PREZCOBIX : Maintain tadalafil dose. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Unknown
Darunavir Ethanolate And Cobicistat Class
Cytochrome P450 3A Inhibitor
Ritonavir Class
Cytochrome P450 3A Inhibitor
Management
Consult your pharmacist
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Darunavir Ethanolate And Cobicistat and your doctor is considering prescribing Ritonavir (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Darunavir Ethanolate And Cobicistat(Prezcobix)+💊 Ritonavir(Norvir)

Severity & Interaction Details

ℹ️
unknown
Interaction documented — severity unclassified
The FDA label notes an interaction but the severity is not classified in our dataset.
Severity scale
MinorContra
On record
Yes
Drug A class
Cytochrome P450 3A Inhibitor
Drug B class
Cytochrome P450 3A Inhibitor
Source
FDA drug label - darunavir ethanolate and cobicistat

What this means in plain English

Switching from darunavir co-administered with ritonavir to PREZCOBIX in patients on bosentan : Maintain bosentan dose. Patients switching from darunavir co-administered with ritonavir to PREZCOBIX : Maintain tadalafil dose.

About Darunavir Ethanolate And Cobicistat and Ritonavir

Darunavir Ethanolate And Cobicistat and Ritonavir both belong to the Cytochrome P450 3A Inhibitor class. You may recognize them by the brand names Prezcobix and Norvir. Both medications are taken by mouth. Ritonavir additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.