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Does Desvenlafaxine Er Interact with Tranylcypromine?

Desvenlafaxine Er and Tranylcypromine have a contraindicated drug interaction according to U.S. FDA drug labeling data. Concomitant use increases risk of serotonin syndrome. Contraindicated with MAOIs intended to treat psychiatric disorders or within 14 days of stopping MAOI. The mechanism involves serotonin syndrome risk. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Desvenlafaxine Er and Tranylcypromine occurs because serotonin syndrome risk. Clinically, this means concomitant use increases risk of serotonin syndrome. contraindicated with maois intended to treat psychiatric disorders or within 14 days of stopping maoi. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Desvenlafaxine Er and your doctor is considering prescribing Tranylcypromine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Desvenlafaxine Er(Khedezla)+💊 Tranylcypromine(Parnate)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:desvenlafaxine er

What this means in plain English

Concomitant use increases risk of serotonin syndrome. Contraindicated with MAOIs intended to treat psychiatric disorders or within 14 days of stopping MAOI.

About Desvenlafaxine Er and Tranylcypromine

You may recognize them by the brand names Khedezla and Parnate. Both medications are taken by mouth. Both Desvenlafaxine Er and Tranylcypromine carry an FDA boxed warning — the agency's most serious safety designation.

What the FDA label says

"Serotonin syndrome risk"

📖 Source: NLP:desvenlafaxine er

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.