Does Dextromethorphan Interact with Methylnaltrexone Bromide?
Dextromethorphan and Methylnaltrexone Bromide have a minor drug interaction according to U.S. FDA drug labeling data. Subcutaneous methylnaltrexone did not significantly affect dextromethorphan metabolism in healthy subjects. The mechanism involves cyp2d6 substrate metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Dextromethorphan and Methylnaltrexone Bromide occurs because cyp2d6 substrate metabolism. Clinically, this means subcutaneous methylnaltrexone did not significantly affect dextromethorphan metabolism in healthy subjects. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Dextromethorphan and your doctor is considering prescribing Methylnaltrexone Bromide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider