Dextromethorphan + Paroxetine Interaction
Moderateinteraction on record
Description
Paroxetine inhibits CYP2D6, increasing dextromethorphan exposure. Decrease dextromethorphan dosage if needed with concomitant paroxetine use.
Mechanism
CYP2D6 inhibition decreases dextromethorphan metabolism
Source: NLP:paroxetine