Dextromethorphan + Terbinafine Hydrochloride Interaction

Moderateinteraction on record

Description

Terbinafine increases dextromethorphan/dextrorphan metabolite ratio by 16- to 97-fold, converting extensive metabolizers to poor metabolizer status. Careful monitoring and dose reduction may be required.

Mechanism

CYP450 2D6 inhibition

Source: NLP:terbinafine hydrochloride