Does Diazepam Interact with Antacids Containing Calcium?
Diazepam and Antacids Containing Calcium have a minor drug interaction according to U.S. FDA drug labeling data. Reduce diazepam peak concentrations by 30% and slow rate of absorption with 20-25 minute delay in peak achievement, but no effect on extent of absorption. The mechanism involves slower rate of absorption. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Diazepam Class
- Benzodiazepine
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Diazepam and Antacids Containing Calcium occurs because slower rate of absorption. Clinically, this means reduce diazepam peak concentrations by 30% and slow rate of absorption with 20-25 minute delay in peak achievement, but no effect on extent of absorption. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Diazepam and your doctor is considering prescribing Antacids Containing Calcium (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider