Does Diazepam Interact with Olanzapine?

Diazepam and Olanzapine have a moderate drug interaction according to U.S. FDA drug labeling data. Diazepam: May potentiate orthostatic hypotension ( 7.1, 7.2 ) Alcohol: May potentiate orthostatic hypotension ( 7.1 ) Carbamazepine: Increased clearance of olanzapine ( 7.1) Fluvoxamine: May increase olanzapine levels ( 7.1 ) Olanzapine and Fluoxetine in Combination: Also refer to the DrugInteractions section of the package insert for Symbyax. (7.1) CNS Acting Drugs: Caution should be used when taken in combination with other centrally acting drugs and alcohol ( 7.2 ) Antihypertensive Agents: Enhanced antihypertensive effect ( 7.2 ) Levodopa and Dopamine Agonists: May antagonize levodopa/dopamine agonists (7.2 ) Other Concomitant Drug Therapy: When using olanzapine in combination with lithium or valproate, refer to the Drug Interactions sections of the package insert for those products ( 7.2 ) 7.1 Potential for Other Drugs to Affect Olanzapine Diazepam — The co-administration of diazepam with olanzapine potentiated the orthostatic hypotension observed with olanzapine [see Drug Interactions (7.2) ]. Diazepam — Olanzapine did not influence the pharmacokinetics of diazepam or its active metabolite N-desmethyldiazepam. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity

Moderate

Diazepam Class

Benzodiazepine

Olanzapine Class

Atypical Antipsychotic

Management

Monitor for effects

Data Source

U.S. FDA via OpenFDA