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Does Diazepam Interact with Venlafaxine Hydrochloride?

Diazepam and Venlafaxine Hydrochloride have a minor drug interaction according to U.S. FDA drug labeling data. Diazepam did not affect venlafaxine or ODV pharmacokinetics, and venlafaxine did not affect diazepam pharmacokinetics or psychomotor effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Diazepam Class
Benzodiazepine
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Diazepam and your doctor is considering prescribing Venlafaxine Hydrochloride (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Diazepam(Valium)+💊 Venlafaxine Hydrochloride(Venlafaxine Hydrochloride)

Severity & Interaction Details

✅
minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
Benzodiazepine
Drug B class
—
Source
NLP:venlafaxine hydrochloride

What this means in plain English

Diazepam did not affect venlafaxine or ODV pharmacokinetics, and venlafaxine did not affect diazepam pharmacokinetics or psychomotor effects.

About Diazepam and Venlafaxine Hydrochloride

Diazepam is a Benzodiazepine. Diazepam is also sold under the brand name Valium. Both medications are taken by mouth. Both Diazepam and Venlafaxine Hydrochloride carry an FDA boxed warning — the agency's most serious safety designation.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.