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Does Diclofenac Sodium And Misoprostol Interact with Furosemide?

Diclofenac Sodium And Misoprostol and Furosemide have a moderate drug interaction according to U.S. FDA drug labeling data. In such high risk patients, monitor for signs of worsening renal function ( 7 ) Diuretics : NSAIDs can reduce natriuretic effect of furosemide and thiazide diuretics. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Diclofenac Sodium And Misoprostol Class
Prostaglandin E1 Analog
Furosemide Class
Loop Diuretic
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Diclofenac Sodium And Misoprostol and your doctor is considering prescribing Furosemide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Diclofenac Sodium And Misoprostol(Diclofenac Sodium Misoprostol)+💊 Furosemide(Disal)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Prostaglandin E1 Analog
Drug B class
Loop Diuretic
Source
FDA drug label - diclofenac sodium and misoprostol

What this means in plain English

In such high risk patients, monitor for signs of worsening renal function ( 7 ) Diuretics : NSAIDs can reduce natriuretic effect of furosemide and thiazide diuretics.

About Diclofenac Sodium And Misoprostol and Furosemide

Diclofenac Sodium And Misoprostol is a Prostaglandin E1 Analog, while Furosemide is a Loop Diuretic. Furosemide is also sold under the brand name Disal. Diclofenac Sodium And Misoprostol is taken by mouth, whereas Furosemide is given by intramuscular injection. Both Diclofenac Sodium And Misoprostol and Furosemide carry an FDA boxed warning — the agency's most serious safety designation.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.