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Does Diclofenac Sodium And Misoprostol Interact with Voriconazole?

Diclofenac Sodium And Misoprostol and Voriconazole have a unknown drug interaction according to U.S. FDA drug labeling data. Co-administration of diclofenac with CYP2C9 inhibitors (e.g., voriconazole) may enhance the exposure and toxicity of diclofenac [see Error! Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Unknown
Diclofenac Sodium And Misoprostol Class
Prostaglandin E1 Analog
Voriconazole Class
Azole Antifungal
Management
Consult your pharmacist
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Diclofenac Sodium And Misoprostol and your doctor is considering prescribing Voriconazole (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Diclofenac Sodium And Misoprostol(Diclofenac Sodium Misoprostol)+💊 Voriconazole(Vfend)

Severity & Interaction Details

ℹ️
unknown
Interaction documented — severity unclassified
The FDA label notes an interaction but the severity is not classified in our dataset.
Severity scale
MinorContra
On record
Yes
Drug A class
Prostaglandin E1 Analog
Drug B class
Azole Antifungal
Source
FDA drug label - diclofenac sodium and misoprostol

What this means in plain English

Co-administration of diclofenac with CYP2C9 inhibitors (e.g., voriconazole) may enhance the exposure and toxicity of diclofenac [see Error!

About Diclofenac Sodium And Misoprostol and Voriconazole

Diclofenac Sodium And Misoprostol is a Prostaglandin E1 Analog, while Voriconazole is an Azole Antifungal. Voriconazole is also sold under the brand name Vfend. Both medications are taken by mouth. Diclofenac Sodium And Misoprostol additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Recent research & FDA safety updates

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.