Does Digitalis Glycosides Interact with Cholestyramine Powder For Suspension?
Digitalis Glycosides and Cholestyramine Powder For Suspension have a major drug interaction according to U.S. FDA drug labeling data. Cholestyramine may reduce digitalis absorption; discontinuance poses hazard if drug was titrated to maintenance level during concurrent use. The mechanism involves binding and reduced absorption; enterohepatic circulation interference. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Cholestyramine Powder For Suspension Class
- Bile Acid Sequestrant
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Digitalis Glycosides and Cholestyramine Powder For Suspension occurs because binding and reduced absorption; enterohepatic circulation interference. Clinically, this means cholestyramine may reduce digitalis absorption; discontinuance poses hazard if drug was titrated to maintenance level during concurrent use. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Digitalis Glycosides and your doctor is considering prescribing Cholestyramine Powder For Suspension (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider