Does Divalproex Sodium Er Interact with Ritonavir?
CDI records a moderate classification for Divalproex Sodium Er and Ritonavir. The stored summary is: Elevates glucuronosyltransferase levels, increasing valproate clearance and potentially decreasing valproate concentrations. The mechanism involves elevation of hepatic glucuronosyltransferase expression. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Ritonavir Class
- Cytochrome P450 3A Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Elevation of hepatic glucuronosyltransferase expression
What To Tell Your Doctor or Pharmacist
If you are taking Divalproex Sodium Er and your doctor is considering prescribing Ritonavir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider