Does Doxercalciferol Interact with Phenobarbital?
CDI records a moderate classification for Doxercalciferol and Phenobarbital. The stored summary is: Enzyme inducer that may enhance the 25-hydroxylation of doxercalciferol. Dose adjustment of doxercalciferol may be necessary. The mechanism involves enhances cyp 27-mediated activation of doxercalciferol. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Doxercalciferol Class
- Vitamin D2 Analog
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Enhances CYP 27-mediated activation of doxercalciferol
What To Tell Your Doctor or Pharmacist
If you are taking Doxercalciferol and your doctor is considering prescribing Phenobarbital (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider