Does Efavirenz Lamivudine And Tenofovir Disoproxil Fumarate Interact with Gentamicin?
CDI records a moderate classification for Efavirenz Lamivudine And Tenofovir Disoproxil Fumarate and Gentamicin. The stored summary is: Coadministration may increase concentrations of tenofovir and/or gentamicin due to competition for active tubular secretion in the kidneys. The mechanism involves competition for renal active tubular secretion. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Efavirenz Lamivudine And Tenofovir Disoproxil Fumarate Class
- Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Competition for renal active tubular secretion
What To Tell Your Doctor or Pharmacist
If you are taking Efavirenz Lamivudine And Tenofovir Disoproxil Fumarate and your doctor is considering prescribing Gentamicin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider