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Does Eltrombopag Interact with Peginterferon Alfa 2a?

Eltrombopag and Peginterferon Alfa 2a have a minor drug interaction according to U.S. FDA drug labeling data. No dose adjustment recommended when coadministered with eltrombopag. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Peginterferon Alfa 2a Class
Interferon alpha
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Eltrombopag and your doctor is considering prescribing Peginterferon Alfa 2a (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Eltrombopag(Eltrombopag Olamine)+💊 Peginterferon Alfa 2a(Pegasys)

Severity & Interaction Details

✅
minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Interferon alpha
Source
NLP:eltrombopag

What this means in plain English

No dose adjustment recommended when coadministered with eltrombopag.

About Eltrombopag and Peginterferon Alfa 2a

Peginterferon Alfa 2a is an Interferon alpha. Peginterferon Alfa 2a is also sold under the brand name Pegasys. Eltrombopag is taken by mouth, whereas Peginterferon Alfa 2a is given by injection under the skin. Both Eltrombopag and Peginterferon Alfa 2a carry an FDA boxed warning — the agency's most serious safety designation.

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.