Does Eluxadoline Interact with Cyclosporine?
CDI records a moderate classification for Eluxadoline and Cyclosporine. The stored summary is: OATP1B1 inhibitor that increases eluxadoline exposure. Requires dose reduction to 75 mg twice daily and monitoring for adverse reactions. The mechanism involves oatp1b1 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Eluxadoline Class
- mu-Opioid Receptor Agonist
- Cyclosporine Class
- Calcineurin Inhibitor Immunosuppressant
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
OATP1B1 inhibition
What To Tell Your Doctor or Pharmacist
If you are taking Eluxadoline and your doctor is considering prescribing Cyclosporine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider