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Does Elvitegravir Cobicistat Emtricitabine And Tenofovir Disoprox Interact with Ketoconazole?

Elvitegravir Cobicistat Emtricitabine And Tenofovir Disoprox and Ketoconazole have a unknown drug interaction according to U.S. FDA drug labeling data. Tricyclic Antidepressants (TCAs) e.g., amitriptyline desipramine imipramine nortriptyline bupropion trazodone Antifungals: itraconazole ketoconazole voriconazole ↑ elvitegravir ↑ cobicistat ↑ itraconazole ↑ ketoconazole ↑ voriconazole When coadministered with STRIBILD, the maximum daily dose of ketoconazole or itraconazole should not exceed 200 mg per day. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity: Unknown
Elvitegravir Cobicistat Emtricitabine And Tenofovir Disoprox Class: Cytochrome P450 3A Inhibitor
Ketoconazole Class: Azole Antifungal
Management: Consult your pharmacist
Data Source: U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Elvitegravir Cobicistat Emtricitabine And Tenofovir Disoprox and your doctor is considering prescribing Ketoconazole (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Never stop or change either medication without first consulting your healthcare provider

💊 Elvitegravir Cobicistat Emtricitabine And Tenofovir Disoprox(Stribild)+💊 Ketoconazole(T8 Keto Flush)

Severity & Interaction Details

ℹ️

unknown

Interaction documented — severity unclassified

The FDA label notes an interaction but the severity is not classified in our dataset.

Severity scale

MinorContra

On record

Yes

Drug A class

Cytochrome P450 3A Inhibitor

Drug B class

Azole Antifungal

Source

FDA drug label - elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate

What this means in plain English

Tricyclic Antidepressants (TCAs) e.g., amitriptyline desipramine imipramine nortriptyline bupropion trazodone Antifungals: itraconazole ketoconazole voriconazole ↑ elvitegravir ↑ cobicistat ↑ itraconazole ↑ ketoconazole ↑ voriconazole When coadministered with STRIBILD, the maximum daily dose of ketoconazole or itraconazole should not exceed 200 mg per day.

About Elvitegravir Cobicistat Emtricitabine And Tenofovir Disoprox and Ketoconazole

Elvitegravir Cobicistat Emtricitabine And Tenofovir Disoprox is a Cytochrome P450 3A Inhibitor, while Ketoconazole is an Azole Antifungal. You may recognize them by the brand names Stribild and Ketodan. Both medications are taken by mouth. Both Elvitegravir Cobicistat Emtricitabine And Tenofovir Disoprox and Ketoconazole carry an FDA boxed warning — the agency's most serious safety designation.

Recent research & FDA safety updates

Live

Auto-aggregated from PubMed E-utilities and FDA safety data.

FDA

FDA Safety Alert: Bisoprolol Fumarate and Hydrochlorothiazide tablets, USP, 2.5 mg/6.25 mg, 100-count bottle, Rx Only,about Elvitegravir Cobicistat Emtricitabine And Tenofovir Disoprox · 2026-02

PubMed

A Trial of a Single-tablet Regimen of Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate for the Initial Treatment of Human Immunodeficiency Virus Type 2 Infection in a Resource-limited Setting: 48-Week Results From Senegal, West Africa.about Elvitegravir Cobicistat Emtricitabine And Tenofovir Disoprox · 2018-10

PubMed

Switching to the single-tablet regimen of elvitegravir, cobicistat, emtricitabine, and tenofovir DF from non-nucleoside reverse transcriptase inhibitor plus coformulated emtricitabine and tenofovir DF regimens: Week 96 results of STRATEGY-NNRTI.about Elvitegravir Cobicistat Emtricitabine And Tenofovir Disoprox · 2017-07

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.