Home›Emtricitabine And Tenofovir Disoproxil Fumarate›Emtricitabine And Tenofovir Disoproxil Fumarate + Ledipasvir

Does Emtricitabine And Tenofovir Disoproxil Fumarate Interact with Ledipasvir?

CDI records a moderate classification for Emtricitabine And Tenofovir Disoproxil Fumarate and Ledipasvir. The stored summary is: ledipasvir/sofosbuvir Monitor patients receiving TRUVADA concomitantly with HARVONI ® (ledipasvir/sofosbuvir) without an HIV-1 protease inhibitor/ritonavir or an HIV-1 protease inhibitor/cobicistat combination for adverse reactions associated with TDF. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.

Evidence status

A current label comparison is not yet available for this record. The summary and severity are stored CDI information; they have not been independently validated on this page against the exact product label.

Confirm the medicine, formulation, route, and applicable warning with your pharmacist or prescriber. Independent clinical review has not been recorded.

Stored CDI classification
Moderate
Emtricitabine And Tenofovir Disoproxil Fumarate Class
Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor
Management
Confirm exact products with your pharmacist
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Emtricitabine And Tenofovir Disoproxil Fumarate and your doctor is considering prescribing Ledipasvir (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Emtricitabine And Tenofovir Disoproxil Fumarate(Truvada)+💊 Ledipasvir(Harvoni)

Severity & Interaction Details

🟡
moderate
Stored CDI classification: moderate
A current source comparison has not been recorded for this claim. The stored classification does not determine the clinical significance for your exact products or circumstances.
Severity scale
MinorContra
On record
Yes
Drug A class
Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor
Drug B class
—
Source
FDA drug label - emtricitabine and tenofovir disoproxil fumarate

What this means in plain English

ledipasvir/sofosbuvir Monitor patients receiving TRUVADA concomitantly with HARVONI ® (ledipasvir/sofosbuvir) without an HIV-1 protease inhibitor/ritonavir or an HIV-1 protease inhibitor/cobicistat combination for adverse reactions associated with TDF.

About Emtricitabine And Tenofovir Disoproxil Fumarate and Ledipasvir

Emtricitabine And Tenofovir Disoproxil Fumarate is a Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor. You may recognize them by the brand names Truvada and Harvoni. Emtricitabine And Tenofovir Disoproxil Fumarate additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: FDA drug label - emtricitabine and tenofovir disoproxil fumarate

Recent research & FDA safety updates

Live

Auto-aggregated from PubMed E-utilities and FDA safety data.

PubMed
A case of bullous fixed drug eruption induced by tenofovir disoproxil fumarate/ emtricitabine.about Emtricitabine And Tenofovir Disoproxil Fumarate · 2026-05

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How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.

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