Does Emtricitabine And Tenofovir Disoproxil Fumarate Interact with Lopinavir And Ritonavir?
Emtricitabine And Tenofovir Disoproxil Fumarate and Lopinavir And Ritonavir have a moderate drug interaction according to U.S. FDA drug labeling data. Lopinavir/ritonavir increases tenofovir concentrations. Monitor for evidence of tenofovir toxicity. The mechanism involves ritonavir inhibits p-glycoprotein and bcrp transporters increasing tenofovir absorption. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Emtricitabine And Tenofovir Disoproxil Fumarate Class
- Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor
- Lopinavir And Ritonavir Class
- Protease Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Emtricitabine And Tenofovir Disoproxil Fumarate and Lopinavir And Ritonavir occurs because ritonavir inhibits p-glycoprotein and bcrp transporters increasing tenofovir absorption. Clinically, this means lopinavir/ritonavir increases tenofovir concentrations. monitor for evidence of tenofovir toxicity. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Emtricitabine And Tenofovir Disoproxil Fumarate and your doctor is considering prescribing Lopinavir And Ritonavir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider