Does Enalaprilat Interact with Spironolactone?
CDI records a moderate classification for Enalaprilat and Spironolactone. The stored summary is: Potassium-sparing diuretic may lead to significant increases in serum potassium when used concomitantly with enalaprilat. Use with caution and monitor serum potassium frequently. The mechanism involves enalaprilat reduces potassium loss, and potassium-sparing diuretics increase serum potassium. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Spironolactone Class
- Aldosterone Antagonist
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Enalaprilat reduces potassium loss, and potassium-sparing diuretics increase serum potassium
What To Tell Your Doctor or Pharmacist
If you are taking Enalaprilat and your doctor is considering prescribing Spironolactone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider