Does Erlotinib Interact with Ranitidine?
CDI records a moderate classification for Erlotinib and Ranitidine. The stored summary is: H-2 receptor antagonist decreases erlotinib exposure. Modify dosing schedule; dose increase unlikely to compensate. The mechanism involves increased gastric ph. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Erlotinib Class
- Kinase Inhibitor
- Ranitidine Class
- Histamine-2 Receptor Antagonist
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased gastric pH
What To Tell Your Doctor or Pharmacist
If you are taking Erlotinib and your doctor is considering prescribing Ranitidine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider