Does Esomeprazole Magnesium Interact with Methotrexate?
CDI records a major classification for Esomeprazole Magnesium and Methotrexate. The stored summary is: Concomitant use may elevate and prolong serum concentrations of methotrexate and metabolite hydroxymethotrexate, possibly leading to methotrexate toxicities. The mechanism involves ppi impairs methotrexate clearance. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Methotrexate Class
- Folate Analog Metabolic Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
PPI impairs methotrexate clearance
What To Tell Your Doctor or Pharmacist
If you are taking Esomeprazole Magnesium and your doctor is considering prescribing Methotrexate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider